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Federal Register Summary for the Week of 18-22 October 2004

COMMERCE

Technology Administration

National Medal of Technology Nomination Evaluation Committee; Notice of Determination for Closure of Meeting

The National Medal of Technology Nomination Evaluation Committee has scheduled a meeting for November 30, 2004.

The Committee was established to assist the Department in executing its responsibilities under 15 U.S.C. 3711. Under this provision, the Secretary of Commerce is responsible for recommending to the President prospective recipients of the National Medal of Technology. The committee's recommendations are made after reviewing all nominations received in response to a public solicitation. The Committee is chartered to have twelve members.

Time and Place: The meeting will begin at 10 a.m. and end at 4 p.m. on November 30, 2004. The meeting will be held in Room 4813 at the U.S. Department of Commerce, 1401 Constitution Avenue, NW., Washington, DC 20230. For further information contact: Mildred S. Porter, Director National Medal of Technology, U.S. Department of Commerce, 1401 Constitution Avenue, NW., Herbert C. Hoover Building, Room 4843, Washington, DC 20230, Phone: 202/482-5572.

If a member of the public would like to submit written comments concerning the committee's affairs at any time before and after the meeting, written comments should be addressed to the Director of the National Medal of Technology as indicated above.

SUPPLEMENTARY INFORMATION: The meeting will be closed to discuss the relative merits of persons and companies nominated for the Medal. Public disclosure of this information would be likely to significantly frustrate implementation of the National Medal of Technology program because premature publicity about candidates under consideration for the Medal, who may or may not ultimately receive the award, would be likely to discourage nominations for the Medal.

Accordingly, I find and determine, pursuant to section 10(d) of the Federal Advisory Committee Act, 5 U.S.C. app. 2, as amended, that the November 30, 2004, meeting may be closed to the public in accordance with section 552b (c) (9) (B) of title 5, United States Code because revealing information about Medal candidates would be likely to significantly frustrate implementation of a proposed agency Action.

Due to closure of the meeting, copies of the minutes of the meeting will not be available, however a copy of the Notice of Determination will be available for public inspection and copying in the office of Mildred Porter, Director, National Medal of Technology, 1401 Constitution Avenue, NW., Herbert Hoover Building, Room 4843, Washington, DC 20230, Phone: 202/482-5572.

http://edocket.access.gpo.gov/2004/04-23399.htm


DEFENSE

National Security Education Board Meeting

AGENCY: National Defense University

ACTION: Notice of meeting.

SUMMARY: Pursuant to Public Law 92-463, notice is hereby given of a forthcoming meeting of the National Security Education Board. The purpose of the meeting is to review and make recommendations to the Secretary concerning requirements established by the David L. Boren National Security Education Act, Title VII of Public Law 102-183, as amended.

DATES: October 29, 2004.

ADDRESSES: The Crystal City Marriott Hotel, 1999 Jefferson Davis Highway, Arlington, VA 22202.

FOR FURTHER INFORMATION CONTACT: Dr. Edmond J. Collier, Deputy Director for Programs, National Security Education Program, 1101 Wilson Boulevard, Suite 1210, Rosslyn PO Box 20010, Arlington, VA 22209-2248; (703) 696-1991. Electronic mail address: colliere@ndu.edu.

SUPPLEMENTARY INFORMATION: The Board meeting is open to the public.

http://edocket.access.gpo.gov/2004/04-23250.htm

Coastal Engineering Research Board (CERB)

AGENCY: Department of Army, DoD.

ACTION: Notice of meeting.

SUMMARY: In accordance with Section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), announcement is made of the following committee meeting:
Name of Committee: Coastal Engineering Research Board (CERB).
Date of Meeting: November 3-4, 2004.
Place: Hilton Washington DC/Silver Spring, 8727 Colesvile Road, Silver Spring, MD, 20910.
Time: 6:30 p.m to 8:30 p.m. (November 3, 2004); 8 a.m to 5 p.m. (November 3, 2004); 8 a.m. to 4:30 p.m. (November 4, 2004).

FOR FURTHER INFORMATION CONTACT: Inquiries and notice of intent to attend the meeting may be addressed to Colonel James R. Rowan, Executive Secretary, Commander, U.S. Army Engineer Research and Development Center, Waterways Experiment Station, 3909 Halls Ferry Road, Vicksburg, MS 39180-6199.

SUPPLEMENTARY INFORMATION: Proposed Agenda: The theme of the meeting is "Ocean Agency Collaboration.'' On Tuesday evening, November 2, there will be an icebreaker. On Wednesday morning, November 3, there will be a presentation on the "U.S. Commission on Ocean Policy Report'' and a panel to discuss "Possible Strategies for Implementing Ocean Policy Report Recommendations.'' The afternoon session will include a presentation entitled "Interagency Collaboration as Part of the Corps Coastal Watershed Activities'' and a panel to discuss ``The Integration of Ocean/Coastal Watershed Perspectives Approach.'' On Thursday morning, November 4, there will be a presentation entitled "Corps' Involvement in Interagency Shoreline Mapping and the Integrated Ocean Observing System'' and a panel to discuss "Interagency Science and Technology Collaboration.'' During the afternoon, the members of the Board will meet in an Executive Session.

These meetings are open to the public; participation by the public is scheduled for 4 p.m. on November 3.

The entire meeting is open to the public but since seating capacity of the meeting room is limited, advance notice of intent to attend, although not required, is requested in order to assure adequate arrangements. Oral participation by public attendees is encouraged during the time scheduled on the agenda; written statements may be submitted prior to the meeting or up to 30 days after the meeting.

http://edocket.access.gpo.gov/2004/04-23229.htm

EDUCATION

Office of Postsecondary Education

International Research and Studies Program; Notice Inviting Application for New Awards for Fiscal Year (FY) 2005

ACTION: Correction.

SUMMARY: On September 23, 2004, a notice inviting applications for new awards under the Office of Postsecondary Education; International Research and Studies Program was published in the Federal Register (69 FR 57011 through 57014). Under Application and Submission Information on page 57012, in column 2, "Page Limit'' section, second sentence, we included the incorrect page limit. The second sentence of the "Page Limit'' section reads "You must limit the narrative to the equivalent of 25 pages using the following standards''. This notice will correct that sentence to read, "You must limit the narrative to the equivalent of 30 pages using the following standards''.

FOR FURTHER INFORMATION CONTACT: Mr. Jose L. Martinez, U.S. Department of Education, 1990 K Street, NW., Room 6010, Washington, DC 20006-8521. Telephone: (202) 502-7635 or by e-mail: jose.martinez@ed.gov.

If you use a telecommunications device for the deaf (TDD), you may call the Federal Information Relay Service (FIRS) at 1-800-877-8339.

Individuals with disabilities may obtain this document in an alternative format (e.g., Braille, large print, audiotape, or computer diskette) on request to the program contact person listed in this section.

Other Information

Electronic Access to This Document: You may view this document, as well as all other documents of this Department published in the Federal Register, in text or Abobe Portable Document Format (PDF) on the Internet at the following site: http://www.ed.gov/news/fedregister.

To use PDF you must have Adobe Acrobat Reader, which is available free at this site. If you have questions about using PDF, call the U.S. Government Printing Office (GPO), toll free, at 1-888-293-6498; or in the Washington, DC, area at (202) 512-1530.

Note: The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.gpoaccess.gov/nara/index.html

http://edocket.access.gpo.gov/2004/04-23687.htm

National Board of the Fund for the Improvement of Postsecondary Education, Department of Education

ACTION: Notice of meeting.

SUMMARY: This notice provides the schedule and a summary of the agenda for an upcoming meeting of the National Board of the Fund for the Improvement of Postsecondary Education (Board). The notice also describes the functions of the Board. Notice of this meeting is required by section 10(a)(2) of the Federal Advisory Committee Act.

DATE AND TIME: November 4, 2004, 12:30 to 4:30 p.m.

ADDRESSES: Renaissance Washington, DC Hotel, 999 Ninth Street, NW., Washington, DC 20001. Telephone: (202) 898-9000.

FOR FURTHER INFORMATION CONTACT: Donald Fischer, U.S. Department of Education, 1990 K Street, NW., Washington, DC 20006-8544; telephone (202) 502-7500; e-mail donald.fischer@ed.gov.

The meeting site is accessible to individuals with disabilities. An individual with a disability who will need an auxiliary aid or service to participate in the meeting (e.g., interpreting service, assistive listening device or materials in an alternate format) should notify the contact person listed in the preceding paragraph as soon as possible.

SUPPLEMENTARY INFORMATION: The National Board of the Fund for the Improvement of Postsecondary Education is established under section 742 of the Higher Education Act of 1965 (20 U.S.C. 1138a). The Board is authorized to advise the Director of the Fund and the Assistant Secretary for Postsecondary Education on (1) priorities for the improvement of postsecondary education, including recommendations for the improvement of postsecondary education and for the evaluation,
dissemination, and adaptation of demonstrated improvements in postsecondary educational practice; and (2) the operation of the Fund, including advice on planning documents, guidelines, and procedures for grant competitions prepared by the Fund.
On Thursday, November 4, 2004, from 12:30 to 4:30 p.m., the Board will meet in open session. The proposed agenda for the meeting will include discussions of the Fund's programs and special initiatives. A special presentation will be made on a U.S.-Brazil Consortia Program project.

Records are kept of all Board proceedings and are available for public inspection at the office of the Fund for the Improvement of Postsecondary Education, 6th Floor, 1990 K Street, NW., Washington, DC 20006-8544 from the hours of 8 a.m. to 4:30 p.m.

http://edocket.access.gpo.gov/2004/E4-2801.htm


ENERGY

Office of Science; Biological and Environmental Research Advisory Committee

AGENCY: Department of Energy.

ACTION: Notice of open meeting.

SUMMARY: This notice announces a meeting of the Biological and Environmental Research Advisory Committee. Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of these meetings be announced in the Federal Register.

DATES: Wednesday, November 3, 2004, 9 a.m. to 5 p.m.; and Thursday, November 4, 2004, 9 a.m. to 12 p.m.

ADDRESSES: American Geophysical Union, 2000 Florida Avenue, NW., Washington, DC 20009.

FOR FURTHER INFORMATION CONTACT: Dr. David Thomassen (301-903-9817; david.thomassen@science.doe.gov), or Ms. Shirley Derflinger (301-903- 0044; shirley.derflinger@science.doe.gov), Designated Federal Officers, Biological and Environmental Research Advisory Committee, U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research, SC-70/Germantown Building, 1000 Independence Avenue, SW., Washington, DC 20585-1290. The most current information concerning this meeting can be found on the Web site: http://www.science.doe.gov/ober/berac/announce.html.

SUPPLEMENTARY INFORMATION: Purpose of the Meeting: To provide advice on a continuing basis to the Director, Office of Science of the Department of Energy, on the many complex scientific and technical issues that arise in the development and implementation of the Biological and Environmental Research Program.
Tentative Agenda
Wednesday, November 3, and Thursday, November 4, 2004:
Comments from Dr. Raymond Orbach, Director, Office of Science.
Report of Subcommittee on Genomics: GTL Facility for the Production and Characterization of Proteins and Molecular Tags.
Report by Dr. Ari Patrinos, Associate Director of Science for Biological and Environmental Research.
Discussion of process that BERAC will use to regularly evaluate BER's interim progress towards achieving its long term performance goals.
Update on the Artificial Retina.
Final Report of the Committee of Visitors review of the Climate Change Research Division.
Preliminary Report of the Committee of Visitors review of the Environmental Remediation Sciences Research Division.
Discussion of BERAC report on future directions and beneficial uses of synthetic genome research.
Presentation on ES Net.
BER Distinguished Scientist Award Program.
Science talk.
New business.
Public comment (10 minute rule).
Public Participation: The day and a half meeting is open to the public. If you would like to file a written statement with the Committee, you may do so either before or after the meeting. If you would like to make oral statements regarding any of the items on the agenda, you should contact David Thomassen or Shirley Derflinger at the address or telephone numbers listed above. You must make your request for an oral statement at least five business days before the meeting. Reasonable provision will be made to include the scheduled oral statements on the agenda. The Chairperson of the Committee will conduct the meeting to facilitate the orderly conduct of business. Public comment will follow the 10-minute rule. This notice is being published less than 15 days before the date of the meeting due to programmatic issues that had to be resolved prior to publication.

Minutes: The minutes of this meeting will be available for public review and copying within 30 days at the Freedom of Information Public Reading Room, IE-190, Forrestal Building, 1000 Independence Avenue, SW., Washington, DC between 9 a.m. and 4 p.m., Monday through Friday, except Federal holidays.

http://edocket.access.gpo.gov/2004/04-23480.htm


ENVIRONMENTAL PROTECTION AGENCY

FIFRA Scientific Advisory Panel; Notice of Public Meeting

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

SUMMARY: There will be a 1-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) to consider and review the N-methyl carbamate risk assessment strategies, and methodologies for exposure assessment.

DATES: The meeting will be held on December 3, 2004, from 8:30 a.m. to approximately 5 p.m., eastern time.

Comments: The deadlines for the submission of requests to present oral comments and the submission of written comments, see Unit I.E. of the SUPPLEMENTARY INFORMATION.

Nominations: Nominations of scientific experts to serve as ad hoc members of the FIFRA SAP for this meeting should be provided on or before October 29, 2004.
Special seating: Requests for special seating arrangements should be made at least 5 business days prior to the meeting.

ADDRESSES: The meeting will be held at the Holiday Inn Rosslyn at Key Bridge, 1900 North Fort Myer Drive, Arlington, VA 22209. The telephone number for the Holiday Inn Rosslyn at Key Bridge is (703) 807-2000.

Comments: Written comments may be submitted electronically (preferred), through hand delivery/courier, or by mail. Follow the detailed instructions as provided in Unit I. of the SUPPLEMENTARY INFORMATION.

Nominations, requests to present oral comments, and specialseating: To submit nominations for ad hoc members of the FIFRA SAP for this meeting, requests for special seating arrangements, or requests to present oral comments, notify the Designated Federal Official (DFO) listed under FOR FURTHER INFORMATION CONTACT. To ensure proper receipt by EPA, your request must identify docket ID number OPP-2004-0349 in the subject line on the first page of your response.FOR FURTHER INFORMATION CONTACT: Joseph E. Bailey, DFO, Office of Science Coordination and Policy (7201M), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460; telephone number: (202) 564-2045; fax number: (202) 564-8382; e-mail addresses: bailey.joseph@epa.gov.

SUPPLEMENTARY INFORMATION:

http://edocket.access.gpo.gov/2004/04-23396.htm

FIFRA Scientific Advisory Panel; Notice of Public Meeting

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

SUMMARY: There will be a 1-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) to consider and review the use of pharmacokinetic data to refine carbaryl risk estimates from oral and dermal exposure.

DATES: The meeting will be held on December 2, 2004, from 8:30 a.m. to approximately 5 p.m., eastern time.

Comments: The deadlines for the submission of requests to present oral comments and the submission of written comments, see Unit I.E. of the SUPPLEMENTARY INFORMATION.

Nominations: Nominations of scientific experts to serve as ad hoc members of the FIFRA SAP for this meeting should be provided on or before October 29, 2004.
Special seating: Requests for special seating arrangements should be made at least 5 business days prior to the meeting.

ADDRESSES: The meeting will be held at the Holiday Inn Rosslyn at Key Bridge, 1900 North Fort Myer Drive, Arlington, VA 22209. The telephone number for the Holiday Inn Rosslyn at Key Bridge is (703) 807-2000.

Comments: Written comments may be submitted electronically (preferred), through hand delivery/courier, or by mail. Follow the detailed instructions as provided in Unit I. of the SUPPLEMENTARY INFORMATION.

Nominations, requests to present oral comments, and special seating: To submit nominations for ad hoc members of the FIFRA SAP for this meeting, requests for special seating arrangements, or requests to present oral comments, notify the Designated Federal Official (DFO) listed under FOR FURTHER INFORMATION CONTACT. To ensure proper receipt by EPA, your request must identify docket ID number OPP-2004-0343 in the subject line on the first page of your response.

FOR FURTHER INFORMATION CONTACT: Joseph E. Bailey, DFO, Office of Science Coordination and Policy (7201M), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460; telephone number: (202) 564-2045; fax number: (202) 564-8382; e-mail addresses: bailey.joseph@epa.gov.

SUPPLEMENTARY INFORMATION:

http://edocket.access.gpo.gov/2004/04-23397.htm


Science Advisory Board Staff Office; Notification of an Upcoming Meeting of the Advisory Council on Clean Air Compliance Analysis

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

SUMMARY: The EPA Science Advisory Board (SAB) Staff Office announces a public teleconference of the Advisory Council on Clean Air Compliance Analysis (Council) to finalize a draft advisory letter prepared by its Health Effects Subcommittee (HES) on the cessation lag issue, i.e., the time lag between reductions in air pollution and reductions in human health effects.

DATES: The public teleconference of the Council will be held on November 1, 2004, from 1 p.m. to 2 p.m. (eastern time).

FOR FURTHER INFORMATION CONTACT: Members of the public who wish to obtain the call-in number and access code or who wish to obtain further information regarding the Council and its subcommittees may contact Dr. Holly Stallworth, Designated Federal Officer, at telephone/voice mail: (202) 343-9867 or via e-mail at: stallworth.holly@epa.gov. General information about the SAB may be found on the SAB Web site at: http://www.epa.gov/sab.

SUPPLEMENTARY INFORMATION: Background: The Council and its subcommittees provide EPA's Office of Air and Radiation (OAR) with advice on the data, methods and analyses conducted by OAR for implementing its programs under the Clean Air Act. Additional background on the Council and its advice was provided in 68 FR 7531-7534.
In its March 2004 Advisory report, posted at http://www.epa.gov/sab/pdf /council-- adv--04002.pdf, the Council HES provided advice on the health science aspects of EPA's analytic blueprint for its second prospective analysis. EPA's OAR and Office of Policy, Economics and Innovation recently requested that the Council clarify its particular advice in this March 2004 report pertaining to cessation lags, i.e., the time delay between reductions in air pollution and reductions in adverse health effects. On September 21, 2004, the HES addressed the Agency's questions in a public teleconference, noticed in 69 FR 54783-54784. The agenda and background documents related to the September 21, 2004, teleconference on the cessation lag issue are posted at: http://www.epa.gov/sab/pdf/ council--hes-- background--info--092104.pdf. Subsequent to this teleconference, the HES drafted an advisory letter summarizing its conclusions. The chartered Council will finalize this draft advisory letter on the November 1, 2004, teleconference.

Availability of Meeting Materials: The HES draft advisory letter and a meeting agenda will be posted on the SAB Web site at: http://www.epa.gov/sab prior to the teleconference.

Procedures for Providing Public Comments: It is the policy of the EPA SAB to accept written public comments of any length, and to accommodate oral public comments whenever possible. The SAB Staff Office expects that public statements presented at the Council meeting will not be repetitive of previously submitted oral or written statements. Oral Comments: In general, each individual or group requesting an oral presentation at a face-to-face meeting will be limited to a total time of ten minutes (unless otherwise indicated). Interested parties should contact the DFO in writing (e-mail, fax or mail--see contact information above) by close of business October 25, 2004, in order to be placed on the public speaker list for the meeting. Written Comments: Although the SAB Staff Office accepts written comments until the date of the meeting (unless otherwise stated), written comments should be received in the SAB Staff Office at least seven business days prior to the meeting date so that the comments may be made available to the panel for their consideration. Comments should be supplied to the DFO at the address/contact information noted above in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat, WordPerfect, Word, or Rich Text files in IBM-PC/Windows 98/2000/XP format).

http://edocket.access.gpo.gov/2004/04-23583.htm


HEALTH AND HUMAN SERVICES

Public Health Service

National Institute of Environmental Health Sciences (NIEHS); National Toxicology Program (NTP); NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM): Availability of Updated Standardized In Vitro Cytotoxicity Test Method Protocols for Estimating Acute Oral Systemic Toxicity; Request for Existing In Vivo and In Vitro Acute Toxicity Data

Summary: NICEATM announces the availability of two updated standardized in vitro cytotoxicity test method protocols to estimate acute oral systemic toxicity in rodents. These two test methods were previously recommended by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) for selecting starting doses for in vivo acute oral systemic toxicity tests (Federal Register Vol. 66, No. 189, pages 49686-49687, September 28, 2001). This approach can reduce the number of animals required for acute oral toxicity testing. NICEATM also requests the submission of existing and future data on chemicals and products tested for both acute oral systemic toxicity and in vitro cytotoxicity using the standardized test method protocols mentioned in this notice. These data will be used to further evaluate the usefulness and limitations of cytotoxicity methods for estimating in vivo acute oral toxicity. The data will also be used to establish a database to support the investigation of other test methods necessary to improve the accuracy of in vitro assessments of acute systemic toxicity.

Availability of Standardized Test Method Protocols for Estimating Starting Doses for In Vivo Acute Oral Toxicity Tests

Updated standardized protocols for two neutral red uptake assays using either BALB/c 3T3 cells or normal human keratinocytes are now available at: http://iccvam.niehs.nih.gov/methods/invitro.htm. These test method protocols have been improved to maximize intra- and inter-laboratory reproducibility and are currently being used for the final phase of a joint NICEATM-European Center for the Validation of Alternative Methods (ECVAM) validation study. NICEATM recommends that these updated test method protocols be used in place of standard operating procedures previously recommended by ICCVAM for two cytotoxicity test methods to estimate starting doses for in vivo acute oral toxicity tests (ICCVAM, 2001b).

Submission of Chemical and Protocol Information/Test Data

In vivo and in vitro acute toxicity testing data for chemicals or products should be sent by mail, fax or e-mail to NICEATM [Dr. William S. Stokes, Director, NICEATM, NIEHS, PO Box 12233, MD EC-17, Research Triangle Park, NC 27709, (phone) 919-541-2384, (fax) 919-541-0947, (e-mail) iccvam@niehs.nih.gov]. Data will be accepted at any time. Data submitted within the next 9 months will be considered during an evaluation of the validation status of the two cytotoxicity methods anticipated in late 2005. Chemical and protocol information/test data submitted in response to this notice may be incorporated in future NICEATM and ICCVAM reports and publications as appropriate.

When submitting chemical and protocol information/test data, please reference this Federal Register notice and provide appropriate contact information (name, affiliation, mailing address, phone, fax, e-mail, and sponsoring organization, as applicable).

NICEATM prefers data to be submitted as copies of pages from study notebooks and/or study reports, if available. Raw data and analyses available in electronic format may also be submitted. Each submission for a chemical should preferably include the following information, as appropriate:
Common and trade name
Chemical Abstracts Service Registry Number (CASRN)
Chemical and/or product class
Commercial source
In vitro basal cytotoxicity test protocol used
In vitro cytotoxicity test results
In vivo acute oral toxicity test protocol used
Individual animal responses at each observation time (if available)
The extent to which the study complied with national or international Good Laboratory Practice (GLP) guidelines
Date and testing organization

Those persons submitting data on chemicals tested for in vitro basal cytotoxicity are referred to the standard test-reporting template recommended for the High Production Volume (HPV) program at http://www.epa.gov/chemrtk/toxprtow.htm or at http://iccvam.niehs.nih.gov/methods/invitro.htm. In vivo data for the same chemicals should be reported as recommended in the test reporting section of the current Environmental Protection Agency (EPA) guideline for acute oral toxicity (EPA, 2002).
Submitted data will be used to further evaluate the usefulness and limitations of in vitro cytotoxicity data for estimating acute oral toxicity, and will be included in a database to support the investigation of other test methods necessary to improve the accuracy of in vitro assessments of acute systemic toxicity.

History

In September 2001, the ICCVAM recommended that in vitro cytotoxicity test methods be considered as a tool for estimating starting doses for in vivo acute systemic toxicity testing studies (Federal Register Vol. 66, No. 189, pages 49686-49687, September 28, 2001.) The recommendations were based on the eport of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity (ICCVAM, 2001a). The Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity (ICCVAM, 2001b) was also made available at that time. The guidance document provided standard operating procedures for two cytotoxicity test methods and instructions for using these assays to estimate starting doses for in vivo testing.
Federal agency responses to the ICCVAM test method recommendations were announced on March 10, 2004 (Federal Register Vol. 69, No. 47, pages 11448-11449). Federal agencies agreed to encourage, to the extent applicable, the use of in vitro tests for determining starting doses for acute systemic toxicity testing. Furthermore, EPA specifically encouraged those participating in the HPV Challenge Program to consider using the recommended in vitro tests as a supplemental component in conducting any new in vivo acute oral toxicity studies for the program (http://www.epa.gov/chemrtk/toxprtow.htm).

A NICEATM-ECVAM validation study was initiated in 2002 to evaluate the usefulness of the two neutral red uptake cytotoxicity assays currently available for predicting starting doses for in vivo acute oral toxicity tests. During the pre-validation phases of the study, the test method protocols were further standardized and revised to improve their intra- and inter-laboratory reproducibility. NICEATM recommends using the revised test method protocols rather than the standard operating procedures outlined in the guidance document (ICCVAM, 2001b.) The guidance document should be consulted for the procedure for calculating starting doses using in vitro cytotoxicity data.

Background Information on ICCVAM and NICEATM

ICCVAM is an interagency committee composed of representatives from fifteen Federal regulatory and research agencies that use, generate, or disseminate toxicological information. ICCVAM promotes the development, validation, regulatory acceptance, and national and international harmonization of toxicological test methods that more accurately assess the safety or hazards of chemicals and products, and test methods that refine, reduce and replace animal use. The ICCVAM Authorization Act of 2000 (available at http://iccvam.niehs.nih.gov/about/PL106545.htm) established ICCVAM as a permanent interagency committee of the NIEHS under the NICEATM. NICEATM administers the ICCVAM and provides scientific support for ICCVAM and ICCVAM-related activities. NICEATM and ICCVAM work collaboratively to evaluate new and improved test methods applicable to the needs of Federal agencies. Additional information about ICCVAM and NICEATM can be found at the following Web site: http://iccvam.niehs.nih.gov/.

References

EPA. 2002. Health Effects Test Guidelines, OPPTS 870.1100, Acute Oral Toxicity, EPA 712-C-02-190. Available at: http://www.epa.gov/opptsfrs/OPPTS_Harmonized/870_Health_Effects_Test_Guidelines/Series/870-1100.pdf.

ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods). 2001a. Report of the international workshop on in vitro methods for assessing acute systemic toxicity. NIH Publication 01-4499. Research Triangle Park, NC: National Institute for Environmental Health Sciences. Available at: http://iccvam.niehs.nih.gov/.

ICCVAM. 2001b. Guidance document on using in vitro data to estimate in vivo starting doses for acute toxicity. NIH Publication 01-4500. Research Triangle Park, NC: National Institute for Environmental Health Sciences. Available at: http://iccvam.niehs.nih.gov/.

http://edocket.access.gpo.gov/2004/04-23335.htm


National Institute of Environmental Health Sciences; Amended Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods: Availability of Video Casting and a Public
Telephone Call-In Line

This notice announces the availability of video casting and a public telephone call-in line for the October 20, 2004 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM). The meeting will be held at the U.S. Environmental Protection Agency (EPA), 109 T.W. Alexander Drive, Research Triangle Park, NC (Building C, Room C111, Auditorium sections A. and B). Additional information about this SACATM meeting was published in a previous Federal Register notice (September 8 (Volume 69, Number 173) pages 54298--54299).

The National Toxicology Program (NTP) is making plans to video cast the SACATM meeting through the Internet at http://www.niehs.nih.gov/external/video.htm. The following information is required for telephone access:
USA Toll Free Number: 800-857-1738 (required).
Passcode: 50250 (required).
Leader Name: Kristina Thayer (required).
Press *6 to mute and unmute.

The NTP has reserved 50 telephone lines for this call and access availability will be on a first come first served basis. Comments from the phone will be solicited during public comment periods identified on the agenda (see below for revised draft agenda). Telephone comments should not exceed two minutes in length and each organization is allowed only one oral slot (in person or by the telephone) per agenda topic. Calls will be taken as time permits and at the discretion of the SACATM chairperson. Every effort will be made to accommodate callers, but the total time allotted for comments received via the telephone will be 30 minutes for the entire meeting. Priority will be given to callers who register to make public comments in advance of the meeting. Registration to present oral public comments or to submit written comments can be completed online at the SACATM meeting site (http://ntp-server.niehs.nih.gov/index.cfm?objectid=26F6530D-BA27-9B29-FAE1657CB6DB907D). Details about the meeting, Internet access and telephone call-in are also available at this site. The video casting
and public telephone call-in are new remote access options for SACATM, thus their technical quality can not be guaranteed.

Revised Draft Agenda

Scientific Advisory Committee on Alternative Toxicological Methods October 20, 2004

U.S. Environmental Protection Agency, Building C, Room C111 (Auditorium sections A. and B), 109 T.W. Alexander Drive, Research Triangle Park, NC 27709. (A photo ID is required to access the EPA
campus.)

8:30 a.m.

Call to Order and Introductions
Welcome and Remarks from the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP)
Welcome and Remarks from the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Chair
Update on Activities of the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and ICCVAM
Update on the European Center for the Validation of Alternative Methods (ECVAM) Workshop Recommendations and Validation Studies
Evaluation of the Under-Prediction Rate for the in vivo Rabbit Dermal Irritation Test
-Public Comment
Preliminary Evaluation of the Under-Prediction Rate for the in vivo Rabbit Ocular Irritation Test
-Public Comment
12 p.m.: Lunch Break (on your own, the EPA campus has a cafeteria)1 p.m.
ICCVAM Nominations
-Public Comment
NTP Roadmap
-Public Comment
ICCVAM Perspectives on Proposed OECD Draft guidance Document on the Validation and International Acceptance of New or Updated Test methods for Hazard Assessment (Guidance Document 34)
General Discussion
4:30 p.m.: Adjourn

http://edocket.access.gpo.gov/2004/04-23559.htm


HOMELAND SECURITY

Notice of Meeting of Homeland Security Science and Technology Advisory Committee

AGENCY: Office of the Under Secretary for Science and Technology, DHS.

ACTION: Notice.

SUMMARY: The Homeland Security Science and Technology Advisory Committee (HSSTAC) will meet in a partially closed session on November 15-16, 2004.

DATES: The HSSTAC will meet in closed session on November 15, 2004, from 8:30 a.m. to 4:30 p.m. and on November 16, 2004, from 8:30 a.m. to 10 a.m. The Committee will meet in open session on November 16, 2004, from 10 a.m. to 12 p.m.

ADDRESSES: The meeting location for the open session is Booz Allen Hamilton, Virginia Square Plaza, 3811 Fairfax Drive, Arlington, VA 22203.

FOR FURTHER INFORMATION CONTACT: Brenda Leckey, Homeland Security Science and Technology Advisory Committee, Department of Homeland Security, Directorate of Science and Technology, Washington, DC 20528; telephone (202) 254-5041; e-mail HSSTAC@dhs.gov.

SUPPLEMENTARY INFORMATION: Notice of this meeting is given under the Federal Advisory Committee Act (FACA), Pub. L. 92-463, as amended (5 U.S.C. app. 2). The HSSTAC will meet for purposes of receiving briefings from its subcommittees on recent activities and findings in support of the annual report to Congress, deliberating subcommittee findings and providing recommendations to the Under Secretary, and determining future subcommittee and committee activities. In accordance with section 10(d) of the Federal Advisory Committee Act, Pub. L. 92-463, as amended (5 U.S.C. app. 2), the Under Secretary for Science and Technology has determined that this HSSTAC meeting will concern unclassified but sensitive matters to homeland security within the meaning of 5 U.S.C. 552b(c)(9)(B) and that, accordingly, the meeting will be partially closed to the public.

Public Attendance: Due to meeting space restrictions, the maximum number of public attendees will be 20. Members of the public will be registered to attend the public session on a first-come, first-served basis per the procedures that follow. Any member of the public who wishes to attend the public session must provide his or her name, affiliation, social security number, and date of birth no later than 5 p.m. e.s.t., Monday, November 8, 2004. Please provide the required information to Brenda Leckey via e-mail at HSSTAC@dhs.gov, or via phone at (202) 254-5721. Persons with disabilities who require special assistance should indicate so in their admittance request. Photo identification will be required for entry into the public session, and everyone in attendance must be present and seated by 10 a.m. on November 16, 2004.

Public Comments: You may submit comments, identified by DHS-2004-0008, by one of the following methods:

EPA Federal Partner EDOCKET Web site: http://www.epa.gov/feddocket. Follow instructions for submitting comments on the Web site. The Department of Homeland Security has joined the Environmental Protection Agency (EPA) online public docket and comment system on its Partner Electronic Docket System (Partner EDOCKET). The Department of Homeland Security and its agencies (excluding the United States Coast Guard and Transportation Security Administration) will use the EPA Federal Partner EDOCKET system. The USCG and TSA [legacy Department of Transportation (DOT) agencies] will continue to use the DOT Docket Management System until full migration to the electronic rulemaking Federal docket management system in 2005.
Federal eRulemaking Portal: http://www.regulations.gov. Follow the instructions for submitting comments.

E-mail: hsstac@dhs.gov. Include DHS-2004-0008 in the subject line of the message.
Fax: (202) 254-6177.

Mail: Homeland Security Science and Technology Advisory Committee, Department of Homeland Security, Washington, DC 20528.

Instructions: All submissions received must include the agency name and docket number for this rulemaking. All comments received will be posted without change to http://www.epa.gov/feddocket, including any personal information provided.
Docket: For access to the docket to read background documents or comments received, go to http://www.epa.gov/feddocket.

http://edocket.access.gpo.gov/2004/04-23575.htm


NATIONAL SCIENCE FOUNDATION

Notice of Intent To Seek Approval To Extend a Current Information Collection

AGENCY: National Science Foundation.

ACTION: Notice and request for comments.

SUMMARY: The National Science Foundation (NSF) is announcing plans to request clearance of this collection. In accordance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995 (Pub. L. 104-13), we are providing an opportunity for public comment on this action. After obtaining and considering public comment, NSF will prepare the submission requesting that OMB approve clearance of this collection for no longer than 3 years.

DATES: Written comments on this notice must be received by December 17, 2004 to be assured of consideration. Comments received after that date will be considered to the extent practicable.

ADDRESSES: Written comments regarding the information collection and requests for copies of the proposed information collection request should be addressed to Suzanne Plimpton, Reports Clearance Officer, National Science Foundation, 4201 Wilson Blvd., Rm. 295, Arlington, VA 22230, or by e-mail to splimpto@nsf.gov.

FOR FURTHER INFORMATION CONTACT: Contact Suzanne H. Plimpton, Reports Clearance Officer, National Science Foundation, 4201 Wilson Boulevard, Suite 295, Arlington, Virginia 22230; telephone (703) 292-7556; or send e-mail to splimpto@nsf.gov. Individuals who use a telecommunications device for the deaf (TDD) may call the Federal Information Relay Service (FIRS) at 1-800-877-8339 between 8 a.m. and 8 p.m., eastern time, Monday through Friday.

SUPPLEMENTARY INFORMATION:
Title of Collection: Application for NATO Advanced Study Institutes Travel Award and NATO Advanced Study Institutes Travel Award Report Form.
OMB Approval Number: 3145-0001.
Expiration Date of Approval: February 28, 2005.
Type of Request: Intent to seek approval to extend a current information collection for three years.
Abstract: The North Atlantic Treaty Organization (NATO) initiated its Advanced Study Institutes Program in 1958 modeled after a small number of very successful summer science "courses'' that were held in Europe and that sought to rebuild Europe's science strength following World War II. The goal was to bring together both students and researchers from the leading centers of research in highly targeted
fields of science and engineering to promote the "American'' approach to advanced learning, spirited give-and-take between students and teachers, that was clearly driving the rapid growth of U.S. research strength. Today the goal remains the same; but due to the expansion of NATO, each year an increasing number of ASIs are held in NATO Partner Countries along with those held in NATO Member Countries. In the spirit of cooperation with this important activity, the Foundation inaugurated in 1959 a small program of travel grants for advanced graduate students to assist with the major cost of such participation, that of transatlantic travel. It remains today a significant means for young scientists and engineers to develop contact with their peers throughout the world in their respective fields of specialization.

The Advanced Study Institutes (ASI) travel awards are offered to advanced graduate students, to attend one of the NATO's ASIs held in the NATO-member and partner countries of Europe. The NATO ASI program is targeted to those individuals nearing the completion of their doctoral studies in science, technology, engineering and mathematics (STEM) who can take advantage of opportunities to become familiar with progress in their respective fields of specialization in other countries.
The Division of Graduate Education (DGE) in the Education and Human Resources (EHR) Directorate administers the NATO ASI Travel Awards Program. The following describes the procedures for the administration of the Foundation's NATO Advanced study Institute (ASI) Travel Awards, which provide travel support for a number of U.S. graduate students to attend the ASIs scheduled for Europe.

Advanced Study Institute Determination

Once NATO has notified DGE that the schedule of institutes is final, and DGE has received the descriptions of each institute, DGE determines which institutes NSF will support. The ASI travel award program supports those institutes that offer instruction in the STEM fields traditionally supported by NSF as published in Guide to Programs. The program will not support institutes that deal with clinical topics, biomedical topics, or topics that have disease-related goals. Examples of areas of research that will not be considered are epidemiology; toxicology; the development or testing of drugs or procedures for their use; diagnosis or treatment of physical or mental disease, abnormality, or malfunction in human beings or animals; and animal models of such conditions. However, the program does support institutes that involve research in bioengineering, with diagnosis or treatment-related goals that apply engineering principles to problems in biology and medicine while advancing engineering knowledge. The program also supports bioengineering topics that aid persons with disabilities. Program officers from other divisions in NSF will be contacted should scientific expertise outside of DGE be required in the determination process.

Solicitation for Nominations

Following the final determination as to which Advanced Study Institutes NSF will support, DGE contacts each institute director to ask for a list of up to 5 nominations to be considered for NSF travel
support.

DGE/EHR Contact With the Individual's Nominated

Each individual who is nominated by a director will be sent the rules of eligibility, information about the amount of funding available, and the forms (NSF Form 1379, giving our Division of Financial Management (DFM) electronic banking information; NSF Form 1310 (already cleared), and NSF Form 192 (Application for International Travel Grant)) necessary for our application process.

The Funding Process

Once an applicant has been selected to receive NSF travel award support, his or her application is sent to DFM for funding. DFM electronically transfers the amount of $1000 into the bank or other financial institution account identified by the awardee.

Our plan is to have the $1000 directly deposited into the awardee's account prior to the purchase of their airline ticket. An electronic message to the awardee states that NSF is providing support in the amount of $100 for transportation and miscellaneous expenses. The letter also states that the award is subject to the conditions in F.L. 27, Attachment to International Travel Grant, which states the U.S. flag-carrier policy.

As a follow-up, each ASI director may be asked to verify whether all NSF awardees attended the institute. If an awardee is identified as not utilizing the funds as prescribed, we contact the awardee to retrieve the funds. However, if our efforts are not successful, we will forward the awardee's name to the Division of Grants and Agreements (DGA), which has procedures to deal with that situation.

We also ask the awardee to submit a final report on an NSF Form 250, which we provide as an attachment to the electronic award message.

Selection of Awardees

The criteria used to select NSF Advanced Study Institute travel awardees are as follows:
1. The applicant is an advanced graduate student.
2. We shall generally follow the order of the nominations, listed by the director of the institute, within priority level.
3. Those who have not attended an ASI in the past will have a higher priority than those who have.
4. Nominees from different institutions and research groups have higher priority than those from the same institution or research group. (Typically, no more than one person is invited from a school or from a
research group.)
Use of the Information: For NSA Form 192, information will be used in order to verify eligibility and qualifications for the award. For NSF Form 250, information will be used to verify attendance at Advanced
Study Institute and will be included in Division annual report.
Estimate of Burden: Form 192--1.5 hours. Form 250--2 hours.
Respondents: Individuals.
Estimated Number of Responses Per Award: 150 responses, broken down as follows: For NSF Form 250, 75 respondents; for NSF Form 192, 75 respondents.
Estimated Total Annual Burden on Respondents: 262.5 hours, broken down by 150 hours for NSF Form 250 (2 hours per 75 respondents); and 112.5 hours for NSF Form 192 (1.5 hours per 75 respondents).
Frequency of Responses: Annually.
Comments: Comments are invited on (a) whether the proposed collection of information is necessary for the proper performance of the functions of the Agency, including whether the information shall have practical utility; (b) the accuracy of the Agency's estimate of the burden of the proposed collection of information; (c) ways to enhance the quality, utility, and clarity of the information on respondents, including through the use of automated collection techniques or other forms of information technology; or (d) ways to minimize the burden of the collection of information on those who are to respond, including through the use of appropriate automated, electronic, mechanical, or other technological collection techniques or other forms of information technology.

http://edocket.access.gpo.gov/2004/04-23204.htm

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